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Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models
Asikainen S.1; Rudgalvyte M.1; Heikkinen L.1; Louhiranta K.1; Lakso M.1; Wong G.1; Nass R.2
2010-05-01
Source PublicationJournal of Molecular Neuroscience
ISSN08958696
Volume41Issue:1Pages:210-218
Abstract

MicroRNAs (miRNAs) play an important role in human brain development and maintenance. To search for miRNAs that may be involved in the pathogenesis of Parkinsons disease (PD), we utilized miRNA microarrays to identify potential gene expression changes in 115 annotated miRNAs in PD-associated Caenorhabditis elegans models that either overexpress human A53T α-synuclein or have mutations within the vesicular catecholamine transporter (cat-1) or parkin (pdr-1) ortholog. Here, we show that 12 specific miRNAs are differentially regulated in the animals overexpressing α-synuclein, five in cat-1, and three in the pdr-1 mutants. The family of miR-64 and miR-65 are co-underexpressed in the α-synuclein transgenic and cat-1 strains, and members of let-7 family co-underexpressed in the α-synuclein and pdr-1 strains; mdl-1 and ptc-1 genes are target candidates for miR-64 and miR-65 and are overexpressed in α-synuclein transgenic as well as miR-64/65 (tm3711) knockout animals. These results indicate that miRNAs are differentially expressed in C. elegans PD models and suggest a role for these molecules in disease pathogenesis. © 2010 Springer Science+Business Media, LLC.

KeywordCaenorhabditis Elegans Microarray Microrna Neurodegeneration Parkinson's Disease Qrt-pcr
DOI10.1007/s12031-009-9325-1
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences
WOS IDWOS:000275905400027
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Cited Times [WOS]:69   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Itä-Suomen yliopisto
2.Indiana University School of Medicine Indianapolis
Recommended Citation
GB/T 7714
Asikainen S.,Rudgalvyte M.,Heikkinen L.,et al. Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models[J]. Journal of Molecular Neuroscience,2010,41(1):210-218.
APA Asikainen S..,Rudgalvyte M..,Heikkinen L..,Louhiranta K..,Lakso M..,...&Nass R..(2010).Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models.Journal of Molecular Neuroscience,41(1),210-218.
MLA Asikainen S.,et al."Global microRNA expression profiling of caenorhabditis elegans Parkinson's disease models".Journal of Molecular Neuroscience 41.1(2010):210-218.
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