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Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans
Rytinki M.M.1; Lakso M.1; Pehkonen P.1; Aarnio V.1; Reisner K.1; Perakyla M.1; Wong G.1; Palvimo J.J.1
2011-10-01
Source PublicationCellular and Molecular Life Sciences
ISSN1420682X 14209071
Volume68Issue:19Pages:3219-3232
Abstract

Small ubiquitin-related modifiers (SUMOs) are important regulator proteins. Caenorhabditis elegans contains a single SUMO ortholog, SMO-1, necessary for the reproduction of C. elegans. In this study, we constructed transgenic C. elegans strains expressing human SUMO-1 under the control of pan-neuronal (aex-3) or pan-muscular (myo-4) promoter and SUMO-2 under the control of myo-4 promoter. Interestingly, muscular overexpression of SUMO-1 or -2 resulted in morphological changes of the posterior part of the nematode. Movement, reproduction and aging of C. elegans were perturbed by the overexpression of SUMO-1 or -2. Genome-wide expression analyses revealed that several genes encoding components of SUMOylation pathway and ubiquitin-proteasome system were upregulated in SUMO-overexpressing nematodes. Since muscular overexpression of SMO-1 also brought up reproductive and mobility perturbations, our results imply that the phenotypes were largely due to an excess of SUMO, suggesting that a tight control of SUMO levels is important for the normal development of multicellular organisms. © 2011 Springer Basel AG.

KeywordC. Elegans Cell Stress Development Gene Expression Monoubiquitylated Histone 2b Muscle Sumo (Small Ubiquitin-related Modifier) Ubiquitin
DOI10.1007/s00018-011-0627-4
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000295327500008
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Itä-Suomen yliopisto
2.University of Tartu
Recommended Citation
GB/T 7714
Rytinki M.M.,Lakso M.,Pehkonen P.,et al. Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans[J]. Cellular and Molecular Life Sciences,2011,68(19):3219-3232.
APA Rytinki M.M..,Lakso M..,Pehkonen P..,Aarnio V..,Reisner K..,...&Palvimo J.J..(2011).Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans.Cellular and Molecular Life Sciences,68(19),3219-3232.
MLA Rytinki M.M.,et al."Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans".Cellular and Molecular Life Sciences 68.19(2011):3219-3232.
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