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JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling
Riveiro A.R.1; Mariani L.1; Malmberg E.1; Amendola P.G.1; Peltonen J.2; Wong G.3; Salcini A.E.1
2017-03-01
Source PublicationDevelopment (Cambridge)
ISSN14779129 09501991
Volume144Issue:5Pages:856-865
AbstractComponents of the KDM7 family of histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated in cases of X-linked mental retardation. However, how PHF8 regulates neurodevelopmental processes and contributes to the disease is still largely unknown. Here, we show that the catalytic activity of a PHF8 homolog in Caenorhabditis elegans, JMJD-1.2, is required non-cell-autonomously for proper axon guidance. Loss of JMJD-1.2 dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16, the overexpression of which is sufficient to induce the axonal defects. Deficiency of either wrt-8 or grl-16, or reduced expression of homologs of genes promoting Hedgehog signaling, restores correct axon guidance in jmjd-1.2 mutants. Genetic and overexpression data indicate that Hedgehog-related genes act on axon guidance through actin remodelers. Thus, our study highlights a novel function of jmjd-1.2 in axon guidance that might be relevant for the onset of X-linked mental retardation and provides compelling evidence of a conserved function of the Hedgehog pathway in C. elegans axon migration.
KeywordAxon guidance C. elegans Epigenetics Hedgehog signaling Histone demethylase Neuronal development
DOI10.1242/dev.142695
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Københavns Universitet
2.Itä-Suomen yliopisto
3.Universidade de Macau
Recommended Citation
GB/T 7714
Riveiro A.R.,Mariani L.,Malmberg E.,et al. JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling[J]. Development (Cambridge),2017,144(5):856-865.
APA Riveiro A.R..,Mariani L..,Malmberg E..,Amendola P.G..,Peltonen J..,...&Salcini A.E..(2017).JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling.Development (Cambridge),144(5),856-865.
MLA Riveiro A.R.,et al."JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling".Development (Cambridge) 144.5(2017):856-865.
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