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Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia
Huang S.-X.1; Feng C.2; Zhou Y.1; Xu G.1; Han Q.-B.1; Qiao C.-F.1; Chang D.C.2; Luo K.Q.2; Xu H.-X.1
2009
Source PublicationJournal of Natural Products
ISSN01633864
Volume72Issue:1Pages:130-135
Abstract

Bioassay-guided fractionation of the acetone extract of the bark of Garcinia oblongifolia has resulted in the isolation of three new xanthones, oblongixanthones A-C (1-3), three new polyprenylated benzoylphloroglucinols, oblongifolins E-G (4-6), and 12 known compounds. Oblongifolins I (5) and J (6) are the first natural products that have similar structural features to those of two known oxidation products of garcinol. The structures of the new compounds 1-6 were characterized by spectroscopic data interpretation. All isolates were assayed for their apoptosis-inducing effects against HeLa-C3 cells. Oblongifolin C (16) was found to be the most potent apoptotic inducer of the compounds evaluated. © 2009 American Chemical Society and American Society of Pharmacognosy.

DOI10.1021/np800496c
URLView the original
Indexed BySCI
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000262761700024
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Cited Times [WOS]:58   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hong Kong Jockey Club Institute of Chinese Medicine
2.Hong Kong University of Science and Technology
Recommended Citation
GB/T 7714
Huang S.-X.,Feng C.,Zhou Y.,et al. Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia[J]. Journal of Natural Products,2009,72(1):130-135.
APA Huang S.-X..,Feng C..,Zhou Y..,Xu G..,Han Q.-B..,...&Xu H.-X..(2009).Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia.Journal of Natural Products,72(1),130-135.
MLA Huang S.-X.,et al."Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia".Journal of Natural Products 72.1(2009):130-135.
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