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Identification and evaluation of apoptotic compounds from Garcinia paucinervis
Gao X.-M.1; Yu T.3; Lai F.S.F.1; Zhou Y.1; Liu X.1; Qiao C.-F.1; Song J.-Z.1; Chen S.-L.4; Luo K.Q.3; Xu H.-X.1
2010-07-15
Source PublicationBioorganic and Medicinal Chemistry
ISSN09680896
Volume18Issue:14Pages:4957-4964
Abstract

Four new compounds, paucinervins A-D (1-4), and 15 known ones were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds were elucidated by spectroscopic evidences. All of the 19 compounds were evaluated for their apoptosis-inducing effects using HeLa-C3 cells which have been genetically engineered to possess a fluorescent biosensor capable of detecting caspase-3 activation. Eight of them were found to activate caspase-3 in HeLa-C3 cells within 72 h at the concentration of 25 μM. Moreover, the values of IC were measured for all four new compounds on HeLa cells using the MTT assay. Among them, compound 2 (paucinervin B) had the lowest IC value of 9.5 μM, while the other three new compounds had much higher IC values of 29.5, 52.5, and 95.6 μM, respectively. This result shows that paucinervin B has the strongest inhibitory effect against HeLa cell growth among these four newly identified paucinervins and it may have the potential to be developed into a new anticancer candidate. © 2010 Elsevier Ltd. All rights reserved.

KeywordApoptosis Caspase-3 Garcinia Paucinervis Hela Cell
DOI10.1016/j.bmc.2010.06.014
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000279744700011
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Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hong Kong Jockey Club Institute of Chinese Medicine
2.Yunnan Minzu University
3.Nanyang Technological University
4.Chinese Academy of Medical Sciences
Recommended Citation
GB/T 7714
Gao X.-M.,Yu T.,Lai F.S.F.,et al. Identification and evaluation of apoptotic compounds from Garcinia paucinervis[J]. Bioorganic and Medicinal Chemistry,2010,18(14):4957-4964.
APA Gao X.-M..,Yu T..,Lai F.S.F..,Zhou Y..,Liu X..,...&Xu H.-X..(2010).Identification and evaluation of apoptotic compounds from Garcinia paucinervis.Bioorganic and Medicinal Chemistry,18(14),4957-4964.
MLA Gao X.-M.,et al."Identification and evaluation of apoptotic compounds from Garcinia paucinervis".Bioorganic and Medicinal Chemistry 18.14(2010):4957-4964.
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