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Identification and evaluation of apoptotic compounds from Garcinia oligantha
Gao X.-M.1; Yu T.2; Cui M.-Z.1; Pu J.-X.5; Du X.5; Han Q.-B.3; Hu Q.-F.1; Liu T.-C.1; Luo K.Q.2; Xu H.-X.4
2012-03-15
Source PublicationBioorganic and Medicinal Chemistry Letters
ISSN0960894X 14643405
Volume22Issue:6Pages:2350-2353
Abstract

Four new compounds, oliganthins A-D (1-4), and one known caged xanthone gaudichaudione H (5) were isolated from the stems of Garcinia oligantha. The structures of the new compounds were elucidated by spectroscopic evidences. All of the five compounds were evaluated for their apoptosis-inducing effects using HeLa-C3 cells which have been genetically engineered to produce a fluorescent biosensor capable of detecting caspase-3 activation. All of them induced cell apoptosis at 10 μM or lower concentrations. The apoptotic activity of oliganthins A, B and gaudichaudione H were further confirmed by detecting the cleavage of PARP, which is the substrate of activated caspase-3, in these compounds-treated cells using the method of Western blot. Moreover, the values of IC were measured for all five compounds on HeLa cells using the MTT assay. Among them, gaudichaudione H had the lowest IC value of 0.90 μM, while the other four new compounds had IC values of 1.58, 1.52, 4.15, and 7.82 μM, respectively. These results show that gaudichaudione H has the strongest apoptosis-inducing effect and cell growth inhibition effect among these xanthones and it may have the potential to be developed into a new anticancer agent. © 2011 Elsevier Ltd. All rights reserved.

KeywordAnticancer Drug Apoptosis Caspase-3 Garcinia Oligantha Xanthone
DOI10.1016/j.bmcl.2012.01.068
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000301285500047
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Cited Times [WOS]:27   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Yunnan Minzu University
2.Nanyang Technological University
3.Hong Kong Baptist University
4.Shanghai University of Traditional Chinese Medicine
5.Kunming Institute of Botany Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Gao X.-M.,Yu T.,Cui M.-Z.,et al. Identification and evaluation of apoptotic compounds from Garcinia oligantha[J]. Bioorganic and Medicinal Chemistry Letters,2012,22(6):2350-2353.
APA Gao X.-M..,Yu T..,Cui M.-Z..,Pu J.-X..,Du X..,...&Xu H.-X..(2012).Identification and evaluation of apoptotic compounds from Garcinia oligantha.Bioorganic and Medicinal Chemistry Letters,22(6),2350-2353.
MLA Gao X.-M.,et al."Identification and evaluation of apoptotic compounds from Garcinia oligantha".Bioorganic and Medicinal Chemistry Letters 22.6(2012):2350-2353.
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