UM
Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
Chin L.K.1; Luo K.Q.1; Park W.2; Je M.2; Tsai J.2; Kwong D.L.2; Liu A.Q.1
2012-05-07
Source PublicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages808-811
AbstractThis paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis. © 2012 IEEE.
DOI10.1109/MEMSYS.2012.6170309
URLView the original
Language英語
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Document TypeConference paper
CollectionUniversity of Macau
Affiliation1.Nanyang Technological University
2.A-Star, Institute of Microelectronics
Recommended Citation
GB/T 7714
Chin L.K.,Luo K.Q.,Park W.,et al. Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis[C],2012:808-811.
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