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Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery
Wu Z.M.3; Ling L.3; Zhou L.Y.2; Guo X.D.3; Jiang W.3; Qian Y.3; Luo K.Q.1; Zhang L.J.3
2012-07-24
Source PublicationNanoscale Research Letters
ISSN19317573 1556276X
Volume7
Abstract

The aim of the present study was to develop the PLGA/HP55 nanoparticles with improved hypoglycemic effect for oral insulin delivery. The insulin-loaded PLGA/HP55 nanoparticles were produced by a modified multiple emulsion solvent evaporation method. The physicochemical characteristics, in vitro release of insulin, and in vivo efficacy in diabetic rats of the nanoparticles were evaluated. The insulin encapsulation efficiency was up to 94%, and insulin was released in a pH-dependent manner under simulated gastrointestinal conditions. When administered orally (50 IU/kg) to diabetic rats, the nanoparticles can decrease rapidly the blood glucose level with a maximal effect between 1 and 8 h. The relative bioavailability compared with subcutaneous injection (5 IU/kg) in diabetic rats was 11.3% ± 1.05%. This effect may be explained by the fast release of insulin in the upper intestine, where it is better absorbed by the high gradient concentration of insulin than other regions. These results show that the PLGA/HP55 nanoparticles developed in the study might be employed as a potential method for oral insulin delivery. © 2012 Wu et al.

KeywordDiabetes Multiple Emulsions Oral Insulin Ph-sensitive Nanoparticles
DOI10.1186/1556-276X-7-299
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000308660900001
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Nanyang Technological University
2.Hong Kong University of Science and Technology
3.South China University of Technology
Recommended Citation
GB/T 7714
Wu Z.M.,Ling L.,Zhou L.Y.,et al. Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery[J]. Nanoscale Research Letters,2012,7.
APA Wu Z.M..,Ling L..,Zhou L.Y..,Guo X.D..,Jiang W..,...&Zhang L.J..(2012).Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery.Nanoscale Research Letters,7.
MLA Wu Z.M.,et al."Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery".Nanoscale Research Letters 7(2012).
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