UM
Effects of hemodynamic shear stress on circulating tumor cells
Liu X.; Fu A.; How Y.H.; Luo K.Q.
2014
Source Publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Pages582-584
AbstractMetastasis is an inefficient process, but a consensus has not been reached as to which steps of metastasis are potentially rate-limiting. In this study, a microfluidic system was developed to mimic the physiological flow profile in the blood vessel to study how hemodynamic shear stress affects circulating tumor cells (CTCs). Breast cancer MDA-MB-231 cells transfected with a fluorescence resonance energy transfer (FRET)-based biosensor (231-C3) were circulated and recovered repeatedly to obtain series of fluid force-selected cell lines. These cells were shown to acquire enhanced survival ability. They also exhibit elongated cell morphology and greater drug resistance compared to parental 231-C3.
KeywordCell survival Circulating tumor cells Hemodynamic shear stress Metastasis
URLView the original
Language英語
Fulltext Access
Document TypeConference paper
CollectionUniversity of Macau
AffiliationNanyang Technological University
Recommended Citation
GB/T 7714
Liu X.,Fu A.,How Y.H.,et al. Effects of hemodynamic shear stress on circulating tumor cells[C],2014:582-584.
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