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Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia
Feng C.4; Huang S.-X.5; Gao X.-M.2; Xu H.-X.1; Luo K.Q.3
2014-05-23
Source PublicationJournal of Natural Products
ISSN15206025 01633864
Volume77Issue:5Pages:1111-1116
Abstract

Twenty compounds from Garcinia oblongifolia were screened for proapoptotic activity using FRET-based HeLa-C3 sensor cells. Among them, oblongifolins F and G (1 and 2), 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran[7,6-b]xanthone (3), nigrolineaxanthone T (4), and garcicowin B (5) showed significant proapoptotic activity at a concentration of 10 μM. Bioassessments were then performed to evaluate the potential of these compounds for therapeutic application. All five compounds showed significant cytotoxicity and caspase-3-activating ability in cervical cancer HeLa cells, with compounds 1 and 2 having the highest potencies. All five compounds specifically induced caspase-dependent apoptosis, which could be prevented by the pan-caspase inhibitor zVAD-fmk. In particular, 3 induced apoptosis through mitotic arrest. Compounds 1-5 displayed similar IC values (3.9-16.5 μM) against the three cancer cell lines HeLa, MDA-MB-435, and HepG2. In addition, compounds 1, 2, and 4 exhibited similar and potent IC values (2.4-5.1 μM) against several breast and colon cancer cell lines, including those overexpressing either HER2 or P-glycoprotein. HER2 and P-glycoprotein are known factors that confer resistance to anticancer drugs in cancer cells. This is the first study on the cytotoxicity, caspase-3-activing ability, and specificity of proapoptotic compounds isolated from G. oblongifolia in HeLa cells. The potential application of these compounds against HER2- or P-glycoprotein-overexpressing cancer cells was investigated. © 2014 The American Chemical Society and American Society of Pharmacognosy.

DOI10.1021/np4007316
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000336510700003
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Shanghai University of Traditional Chinese Medicine
2.Yunnan Minzu University
3.Nanyang Technological University
4.Hong Kong University of Science and Technology
5.Kunming Institute of Botany Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Feng C.,Huang S.-X.,Gao X.-M.,et al. Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia[J]. Journal of Natural Products,2014,77(5):1111-1116.
APA Feng C.,Huang S.-X.,Gao X.-M.,Xu H.-X.,&Luo K.Q..(2014).Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia.Journal of Natural Products,77(5),1111-1116.
MLA Feng C.,et al."Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia".Journal of Natural Products 77.5(2014):1111-1116.
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