UM
Gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy
Kannadorai R.K.; Chiew G.G.Y.; Luo K.Q.; Liu Q.
2015
Source PublicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9537
AbstractThe transverse and longitudinal plasmon resonance in gold nanorods can be exploited to localize the photothermal therapy and influence the fluorescence to monitor the treatment outcome at the same time. While the longitudinal plasmon peak contributes to the photothermal effect, the transverse peak can enhance fluorescence. After cells take in PEGylated nanorods through endocytosis, autofluorescence from endogenous fluorophores such as nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) in the mitochondria is enhanced two times, which is a good indicator of the respiratory status of the cell. When cells are illuminated continuously with near infrared laser, the temperature reaches the hyperthermic region within the first four minutes, which demonstrates the efficiency of gold nanorods in photothermal therapy. The cell viability test and autofluorescence intensity show good correlation indicating the progress of cell death over time.
Keywordautofluorescence cell viability fluorescence enhancement gold nanorods Hyperthermia photothermal therapy
DOI10.1117/12.2183581
URLView the original
Language英語
Fulltext Access
Citation statistics
Document TypeConference paper
CollectionUniversity of Macau
AffiliationNanyang Technological University
Recommended Citation
GB/T 7714
Kannadorai R.K.,Chiew G.G.Y.,Luo K.Q.,et al. Gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy[C],2015.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Kannadorai R.K.]'s Articles
[Chiew G.G.Y.]'s Articles
[Luo K.Q.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Kannadorai R.K.]'s Articles
[Chiew G.G.Y.]'s Articles
[Luo K.Q.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Kannadorai R.K.]'s Articles
[Chiew G.G.Y.]'s Articles
[Luo K.Q.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.