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Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles
Gao Y.3; Wang Y.1; Fu A.3; Shi W.3; Yeo D.3; Luo K.Q.3; Ow H.1; Xu C.3
2015-02-21
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume3Issue:7Pages:1245-1253
Abstract

Stem cell tracking can reveal the underlying biological processes of stem-cell-based therapies such as the migration and biodistribution of human mesenchymal stem cells (hMSCs) in cancer therapy. Nanoparticle-based contrast agents offer unprecedented opportunities for achieving this goal due to their unique and tunable imaging capabilities. However, most nanoparticles are still in the process of development due to challenges such as retention time and safety issues, and are inaccessible to most researchers. In this article, we investigate the potential application of core-shell fluorescent silica nanoparticles (i.e. C dots), which are commercially available and approved by the FDA for clinical trials. Specifically we demonstrate that 500 nm C dots have prolonged cellular retention (up to one month), minimal contrast agent transfer (at least three weeks) between cells in a co-culture Boyden chamber system, and minimal influence on the hMSC properties including viability, proliferation, differentiation, and tropism to tumor cells.

DOI10.1039/c4tb01452a
URLView the original
Indexed BySCI
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000349617600009
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Citation statistics
Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hybrid Silica Technologies
2.Aramco Research Center
3.Nanyang Technological University
Recommended Citation
GB/T 7714
Gao Y.,Wang Y.,Fu A.,et al. Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles[J]. Journal of Materials Chemistry B,2015,3(7):1245-1253.
APA Gao Y..,Wang Y..,Fu A..,Shi W..,Yeo D..,...&Xu C..(2015).Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles.Journal of Materials Chemistry B,3(7),1245-1253.
MLA Gao Y.,et al."Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles".Journal of Materials Chemistry B 3.7(2015):1245-1253.
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