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Three-dimensional diffuse optical tomography of osteoarthritis: Initial results in the finger joints
Yuan Z.; Zhang Q.; Sobel E.; Jiang H.
2007-05-01
Source PublicationJournal of Biomedical Optics
ISSN10833668 15602281
Volume12Issue:3
AbstractThis work presents a pilot study to show the potential of an emerging imaging modality, near-infrared diffuse optical tomography (DOT), for the diagnosis of osteoarthritis (OA). We report quantitative absorption and scattering images of joint tissue that allow for differentiation between diseased and healthy joints. An automatic, multichannel optical imaging system is used to image finger joints from two OA patients and three healthy volunteers. 3-D optical images of the joint tissue are recovered using a finite-element-based reconstruction algorithm. The reconstructed images demonstrate differences in optical properties at the joint region (cartilage/synovial fluid) between the OA and healthy joints. Quantitative analysis from the patients and healthy volunteers also indicate that the recovered joint sizes are consistent with those from x-ray findings. The results of this pilot study show potential for quantitative imaging and diagnosis of early OA by DOT. © 2007 Society of Photo-Optical Instrumentation Engineers.
KeywordDiffuse optical imaging Finger joint Finite element method Osteoarthritis Reconstruction algorithm
DOI10.1117/1.2737420
URLView the original
Language英語
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Cited Times [WOS]:46   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniversity of Florida
Recommended Citation
GB/T 7714
Yuan Z.,Zhang Q.,Sobel E.,et al. Three-dimensional diffuse optical tomography of osteoarthritis: Initial results in the finger joints[J]. Journal of Biomedical Optics,2007,12(3).
APA Yuan Z.,Zhang Q.,Sobel E.,&Jiang H..(2007).Three-dimensional diffuse optical tomography of osteoarthritis: Initial results in the finger joints.Journal of Biomedical Optics,12(3).
MLA Yuan Z.,et al."Three-dimensional diffuse optical tomography of osteoarthritis: Initial results in the finger joints".Journal of Biomedical Optics 12.3(2007).
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