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Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints
Yuan Z.; Zhang Q.; Sobel E.S.; Jiang H.
2008-12-01
Source PublicationJournal of Biomedical Optics
ISSN10833668 15602281
Volume13Issue:4
Abstract

We describe a multimodality imaging approach that combines x-ray tomosynthesis with near-infrared diffuse optical tomography (DOT) for high-resolution imaging of osteoarthritis in the finger joints. In this approach, we take advantage of high resolution x-ray imaging particularly of the bones and incorporate the fine structural maps obtained from x ray as a priori information into DOT reconstructions. To realize this multi-modality approach, we constructed a hybrid imaging platform that integrated a C-arm-based x-ray tomosynthetic system with a multichannel optic-fiber-based DOT system. We also implemented improved hybrid regularization-based reconstruction algorithms that have shown to be especially effective for high-resolution modality-guided DOT. Initial evaluation of our x-ray-guided DOT reconstruction approach in the finger joints shows that spatial resolution of DOT can be enhanced dramatically when the three-dimensional geometry of bones is known a priori. In particular, the improved quantitative capability of imaging absorption and scattering coefficients of the joint tissues allows for more accurate diagnosis of osteoarthritis over x-ray radiography or DOT alone. © 2008 Society of Photo-Optical Instrumentation Engineers.

KeywordDiffuse Optical Tomography Finger Joints Multimodality Imaging Osteoarthritis x Rays
DOI10.1117/1.2965547
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000259901000030
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Cited Times [WOS]:45   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniversity of Florida
Recommended Citation
GB/T 7714
Yuan Z.,Zhang Q.,Sobel E.S.,et al. Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints[J]. Journal of Biomedical Optics,2008,13(4).
APA Yuan Z.,Zhang Q.,Sobel E.S.,&Jiang H..(2008).Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints.Journal of Biomedical Optics,13(4).
MLA Yuan Z.,et al."Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints".Journal of Biomedical Optics 13.4(2008).
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