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Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: An initial study
Yuan Z.1; Xiao J.2; Sun Y.1; Sobel E.S.1; He J.2; Jiang H.1
2011-04-12
Source PublicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
AbstractWe present for the first time in vivo experimental evidence that multispectral quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a multispectral PAT scanner. Images of tissue physiological/functional parameters including oxy-hemoglobin, deoxyhemoglobin, oxygen saturation and water content along with tissue acoustic velocity of all the examined joints were simultaneously recovered using a finite element reconstruction algorithm for multispectral photoacoustic measurements. The recovered multispectral photoacoustic images show that the OA joints have significantly elevated water content, decreased oxygen saturation, and increased acoustic velocity compared to the normal joints. © 2011 Copyright SPIE - The International Society for Optical Engineering.
DOI10.1117/12.879439
URLView the original
Language英語
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Document TypeConference paper
CollectionUniversity of Macau
Affiliation1.University of Florida
2.Central South University China
Recommended Citation
GB/T 7714
Yuan Z.,Xiao J.,Sun Y.,et al. Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: An initial study[C],2011.
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