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Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway
Wang, Anqi1; Wang, Shengpeng1; Zhou, Fayang1; Li, Peng1; Wang, Yitao1; Gan, Lishe2; Lin, Ligen1
2018-05
Source PublicationBIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
Volume101Pages:334-341
Abstract

Physalin B (PB), one of the major active steroidal constituents of Cape gooseberry (Physalis alkekengi L.), possesses a wide spectrum of biological activities. Although the anticancer activity of PB was reported in previous studies, the underlying mechanisms are still not well stated. In this study, the anticancer effect and the underlying mechanisms of PB were investigated in breast cancer cells. PB significantly reduced the viability of three human breast cancer cell lines, MCF-7, MDA-MB-231 and T-47D, in a concentration-and time-dependent manner. PB induced cell cycle arrest at G2/M phase and promoted cleavage of PARP (poly (ADP-ribose) polymerase), caspases 3, caspase 7 and caspase 9 to stimulate cell apoptosis. Further studies showed that PB induced breast cancer cells apoptosis in a p53-dependent manner in MCF-7 cells. PB also suppressed the phosphorylation of Akt (protein kinase B) and PI3K (phosphoinositide 3-kinase), and increased the phosphorylation of GSK-3 beta (glycogen synthase kinase 3 beta). Taken together, our results indicated that PB might serve as a potential therapeutic agent for breast cancer.

KeywordPhysalin b Breast Cancer Cell Cycle Apoptosis P53 Akt
DOIhttp://doi.org/10.1016/j.biopha.2018.02.094
URLView the original
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000429586400039
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorGan, Lishe
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, PR China
2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Anqi,Wang, Shengpeng,Zhou, Fayang,et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,101:334-341.
APA Wang, Anqi.,Wang, Shengpeng.,Zhou, Fayang.,Li, Peng.,Wang, Yitao.,...&Lin, Ligen.(2018).Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway.BIOMEDICINE & PHARMACOTHERAPY,101,334-341.
MLA Wang, Anqi,et al."Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway".BIOMEDICINE & PHARMACOTHERAPY 101(2018):334-341.
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