UM  > 健康科學學院
Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state
Lu F.-M.2; Zhou J.-S.1; Wang X.-P.1; Xiang Y.-T.2; Yuan Z.2
2017-05-20
Source PublicationNeuroscience
ISSN18737544 03064522
Volume351Pages:96-107
Abstract

Conduct disorder (CD) is a developmental disorder defined by a repetitive and persistent display of antisocial and aggressive behaviors that violates the rights of others or basic social rules. Recently, resting-state functional magnetic resonance imaging (rsfMRI) has been widely adopted to investigate the altered intrinsic neural activities and the disrupted endogenous brain connectivity of CD. In this study, functional connectivity density (FCD) mapping, a newly developed ultrafast voxel-wise method based on rsfMRI, was applied for the first time to examine the changes in the brain functional connectivity in CD at the voxel level. We assessed the differences in FCD between eighteen male adolescents with CD and eighteen typically-developing (TD) individuals. Then, the identified brain regions in which CD patients and healthy controls exhibited significant difference in FCD were extracted to calculate the correlations between measures of FCD values and clinical data. We discovered that compared to healthy controls, CD patients showed increased short-range FCD in the default-mode network including the bilateral posterior cingulate cortex (PCC) and the bilateral precuneus (PCUN). More importantly, increased short-range FCD values in the bilateral PCC, the bilateral PCUN, and increased long-range FCD values in the left MCC showed significant correlations with the impulsivity. Overall, these results suggested that the FCD abnormalities in CD patients occurred in brain regions known to be involved in cognition, emotion and visual perception.

KeywordConduct Disorder Default-mode Network Functional Connectivity Density Resting-state Fmri
DOI10.1016/j.neuroscience.2017.03.040
URLView the original
Indexed BySCI
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000401303800009
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Second Xiangya Hospital of Central-South University
2.Universidade de Macau
Recommended Citation
GB/T 7714
Lu F.-M.,Zhou J.-S.,Wang X.-P.,et al. Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state[J]. Neuroscience,2017,351:96-107.
APA Lu F.-M.,Zhou J.-S.,Wang X.-P.,Xiang Y.-T.,&Yuan Z..(2017).Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state.Neuroscience,351,96-107.
MLA Lu F.-M.,et al."Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state".Neuroscience 351(2017):96-107.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lu F.-M.]'s Articles
[Zhou J.-S.]'s Articles
[Wang X.-P.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lu F.-M.]'s Articles
[Zhou J.-S.]'s Articles
[Wang X.-P.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu F.-M.]'s Articles
[Zhou J.-S.]'s Articles
[Wang X.-P.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.