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Diffusion tensor imaging tractography reveals disrupted white matter structural connectivity network in healthy adults with insomnia symptoms
Lu F.-M.5; Dai J.2; Couto T.A.5; Liu C.-H.4; Chen H.1; Lu S.-L.3; Tang L.-R.3; Tie C.-L.3; Chen H.-F.1; He M.-X.2; Xiang Y.-T.5; Yuan Z.5
2017-11-30
Source PublicationFrontiers in Human Neuroscience
ISSN16625161
Volume11
Abstract

Neuroimaging studies have revealed that insomnia is characterized by aberrant neuronal connectivity in specific brain regions, but the topological disruptions in the white matter (WM) structural connectivity networks remain largely unknown in insomnia. The current study uses diffusion tensor imaging (DTI) tractography to construct the WM structural networks and graph theory analysis to detect alterations of the brain structural networks. The study participants comprised 30 healthy subjects with insomnia symptoms (IS) and 62 healthy subjects without IS. Both the two groups showed smallworld properties regarding their WM structural connectivity networks. By contrast, increased local efficiency and decreased global efficiency were identified in the IS group, indicating an insomnia-related shift in topology away from regular networks. In addition, the IS group exhibited disrupted nodal topological characteristics in regions involving the fronto-limbic and the default-mode systems. To our knowledge, this is the first study to explore the topological organization of WM structural network connectivity in insomnia. More importantly, the dysfunctions of large-scale brain systems including the fronto-limbic pathways, salience network and default-mode network in insomnia were identified, which provides new insights into the insomnia connectome. Topology-based brain network analysis thus could be a potential biomarker for IS.

KeywordDiffusion Tensor Imaging Tractography Graph Theoretical Analysis Insomnia Small-world Network White Matter
DOI10.3389/fnhum.2017.00583
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000416541200003
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.University of Electronic Science and Technology of China
2.Chengdu Mental Health Center
3.Beijing An Ding Hospital, Capital Medical University
4.Capital Medical University China
5.Universidade de Macau
Recommended Citation
GB/T 7714
Lu F.-M.,Dai J.,Couto T.A.,et al. Diffusion tensor imaging tractography reveals disrupted white matter structural connectivity network in healthy adults with insomnia symptoms[J]. Frontiers in Human Neuroscience,2017,11.
APA Lu F.-M..,Dai J..,Couto T.A..,Liu C.-H..,Chen H..,...&Yuan Z..(2017).Diffusion tensor imaging tractography reveals disrupted white matter structural connectivity network in healthy adults with insomnia symptoms.Frontiers in Human Neuroscience,11.
MLA Lu F.-M.,et al."Diffusion tensor imaging tractography reveals disrupted white matter structural connectivity network in healthy adults with insomnia symptoms".Frontiers in Human Neuroscience 11(2017).
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