UM  > 健康科學學院
Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR i and II windows
Gao D.Y.2; Ji X.2; Wang J.L.2; Wang Y.T.2; Li D.L.2; Liu Y.B.2; Chang K.W.2; Qu J.L.1; Zheng J.2; Yuan Z.2
2018
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume6Issue:5Pages:732-739
Abstract

The rapid rise of drug- and multi-drug resistant pathogenic bacteria constitutes an increasing risk to global public health. Thus, it is essential to develop new agents and/or strategies to overcome the antibiotic resistance crisis. Herein, ultra-small protein-based nanoparticles (NPs) with absorption covering both the near-infrared (NIR) I and II windows were constructed as novel antibacterial agents, which introduced a killing strategy utilizing the synergistic photothermal and photodynamic effects. The agent engineered by the conjugation of Ce6 molecules to ultra-small hydrophilic protein-modified copper sulfide NPs can transfer light energy into thermal energy for photothermal therapy and produce reactive oxygen species for photodynamic therapy. Under the irradiation of both NIR I and II lasers, the agent demonstrated a potent bacteria killing activity on both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) in vitro bacteria with high efficacy and safety. Furthermore, the as-prepared NPs also displayed an efficient in vivo bactericidal activity in a mouse model as monitored by measuring the photoacoustic signals of the blood vessels around the infection site. Consequently, leveraging the synergistic photothermal and photodynamic effects, the as-designed ultra-small NIR NPs may eliminate the emergence of drug resistance due to the mechanical destruction of the bacteria cell, thus representing a promising approach to control the antibiotic resistance crisis.

DOI10.1039/c7tb02990j
URLView the original
Indexed BySCI
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000423898100004
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Institute of Chinese Medical Sciences
Affiliation1.Shenzhen University
2.Universidade de Macau
Recommended Citation
GB/T 7714
Gao D.Y.,Ji X.,Wang J.L.,et al. Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR i and II windows[J]. Journal of Materials Chemistry B,2018,6(5):732-739.
APA Gao D.Y..,Ji X..,Wang J.L..,Wang Y.T..,Li D.L..,...&Yuan Z..(2018).Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR i and II windows.Journal of Materials Chemistry B,6(5),732-739.
MLA Gao D.Y.,et al."Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR i and II windows".Journal of Materials Chemistry B 6.5(2018):732-739.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao D.Y.]'s Articles
[Ji X.]'s Articles
[Wang J.L.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao D.Y.]'s Articles
[Ji X.]'s Articles
[Wang J.L.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao D.Y.]'s Articles
[Ji X.]'s Articles
[Wang J.L.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.