UM
Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations
Chan, TengIan; Ouyang, Defang
2018-05
Source PublicationASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN1818-0876
Volume13Issue:3Pages:248-254
AbstractDissolution molecular mechanism of solid dispersions still remains unclear despite thousands of reports about this technique. The aim of current research was to investigate the molecular dissolution mechanism of solid dispersions by molecular dynamics simulations. The formation of ibuprofen/polymer solid dispersions was modeled by the simulated annealing method. After that, the models of solid dispersions were immersed into the water box with 25-30 A thicknesses and 50-100 ns MD simulations were performed to all systems. Simulation results showed various dissolution behaviors in different particle sizes and various polymers of solid dispersions. Small-sized particles of solid dispersions dissolved quickly in the water, while the large particles of PEG or PVP-containing solid dispersions gradually swelled in the dissolution process and drug molecules may aggregate together. In the dissolution process, the carboxylic groups of ibuprofen molecules turned its direction from polymer molecules to external water box and then the drug molecules left the polymer coils. At the same time, polymer coils gradually relaxed and became free polymer chains in the solution. In addition, solid dispersion with poloxamer could prevent the precipitate of drug molecules in the dissolution process, which is different from those of PEG or PVP-containing systems. This research provided us clear images of dissolution process of solid dispersions at the molecular level. (C) 2018 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.
KeywordSolid dispersion Molecular modeling Dissolution process Ibuprofen
DOI10.1016/j.ajps.2017.07.011
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000432445400006
PublisherHONG KONG ASIAMED PUBLISH HOUSE
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Chan, TengIan,Ouyang, Defang. Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2018,13(3):248-254.
APA Chan, TengIan,&Ouyang, Defang.(2018).Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,13(3),248-254.
MLA Chan, TengIan,et al."Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 13.3(2018):248-254.
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