UM
Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: A novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging
Gao D.3; Zhang P.1; Liu Y.3; Sheng Z.1; Chen H.2; Yuan Z.3
2018-11-14
Source PublicationNanoscale
ISSN20403372 20403364
Volume10Issue:42Pages:19742-19748
AbstractEngineering conjugated polymer nanoparticles (CPNs) with an easily-modified surface is essential to construct multifunctional nanoprobes as contrast agents for dual-modal photoacoustic (PA) and fluorescence imaging, which can take advantages of the complementary information from a single modality. In this study, an abundant protein with plenty of functional groups was introduced for the first time to produce easily-modified CPNs, leading to a robust nanoplatform to engineer PA-based multifunctional nanoprobes due to their strong optical absorption in the near-infrared region. Meanwhile, the bovine serum albumin (BSA)-modified CPNs were further engineered by introducing gold clusters in situ, which can serve as fluorescent nanoprobes for dual-modal molecular imaging. In particular, the developed nanoplatform exhibited superior stability and excellent biocompatibility, making it an ideal candidate for various cancer-theranostics applications. More importantly, our imaging results demonstrated that the BSA-modified CPNs were excellent candidates to design PA-based contrast agents for multimodal imaging using the function of the protein. In addition, other functional blocks can also be added to the nanoplatform based on its easily-modified surface, making it a general method for the construction of multifunctional nanoprobes for disease theranostics.
DOI10.1039/c8nr06197a
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shenzhen Institute of Advanced Technology
2.XiangTan University
3.Universidade de Macau
Recommended Citation
GB/T 7714
Gao D.,Zhang P.,Liu Y.,et al. Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: A novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging[J]. Nanoscale,2018,10(42):19742-19748.
APA Gao D.,Zhang P.,Liu Y.,Sheng Z.,Chen H.,&Yuan Z..(2018).Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: A novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging.Nanoscale,10(42),19742-19748.
MLA Gao D.,et al."Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: A novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging".Nanoscale 10.42(2018):19742-19748.
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