UM  > 個人在本單位外知識產出
Recent progress in the biology and physiology of sirtuins
Toren Finkel1; Chu-Xia Deng2; Raul Mostoslavsky3
2009-07-30
Source Publicationnature
ISSN0028-0836
Volume460Issue:7225Pages:587-591
Abstract

The sirtuins are a highly conserved family of NAD1-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

DOIhttp://doi.org/10.1038/nature08197
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000268454300041
Fulltext Access
Citation statistics
Cited Times [WOS]:874   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
Corresponding AuthorChu-Xia Deng
Affiliation1.Translational Medicine Branch, National Heart Lung and Blood Institute
2.Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
3.The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.
Recommended Citation
GB/T 7714
Toren Finkel,Chu-Xia Deng,Raul Mostoslavsky. Recent progress in the biology and physiology of sirtuins[J]. nature,2009,460(7225):587-591.
APA Toren Finkel,Chu-Xia Deng,&Raul Mostoslavsky.(2009).Recent progress in the biology and physiology of sirtuins.nature,460(7225),587-591.
MLA Toren Finkel,et al."Recent progress in the biology and physiology of sirtuins".nature 460.7225(2009):587-591.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Toren Finkel]'s Articles
[Chu-Xia Deng]'s Articles
[Raul Mostoslavsky]'s Articles
Baidu academic
Similar articles in Baidu academic
[Toren Finkel]'s Articles
[Chu-Xia Deng]'s Articles
[Raul Mostoslavsky]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Toren Finkel]'s Articles
[Chu-Xia Deng]'s Articles
[Raul Mostoslavsky]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.