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Glucomannan Biomaterials Targeting C-type Lectin Receptors For Drug Delivery And Tissue Regeneration
Xiudan Zhan; Yiming Niu; Chunming Wang
2014-09-26
Abstract

C-type lectin (CLEC) is a family of immune cell receptors that can bind carbohydrate molecules and mediate both innate and adaptive immune responses. Interactions between carbohydrates and major CLECs initiate endocytosis and other cellular events that are critical for tissue regeneration. In our study, we have developed two glucomannan polymers into three biomaterial types (oxBSP, acBSP and sKGM) in the forms of nanoparticles and injectable gels. We evaluated the performance of oxBSP as drugdelivery vehicles in both in vitro and in vivo models, assessed the potential of acBSP as tissue engineering scaffolds, and tested the ability of sKGM in promoting wound healing in situ. Our results suggested that the oxBSP-based nanoconjugates exhibited high affinity for macrophage mannose receptors, acBSP supported embryonic stem cells adhesion, and sKGM had the potential to sequester nutrient proteins in the wound fluid and consequently enhance wound healing. Our series of studies reveal the high potential of exploiting the interactions between CLECs and glucomannan-based biomaterials for drug delivery, tissue engineering and regenerative medicine.

URLView the original
Author of SourceKorean Tissue Engineering and Regenerative Medicine Society (KTERMS)
Source Publication2014 Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Annual Conference (TEMRIS-AP 2014)
Conference Date24th-27th Sep 2014
Conference PlaceEXCO, Daegu, Korea
Language英语
Fulltext Access
Document TypePresentation
CollectionInstitute of Chinese Medical Sciences
AffiliationInstitute of Chinese Medical Sciences, University of Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiudan Zhan,Yiming Niu,Chunming Wang. Glucomannan Biomaterials Targeting C-type Lectin Receptors For Drug Delivery And Tissue Regeneration[Z]. 2014 Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Annual Conference (TEMRIS-AP 2014),24th-27th Sep 2014.
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