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Novel lncRNA LINC00844 regulates prostate cancer cell migration and invasion through AR signaling
Lingadahalli S.1; Jadhao S.1; Sung Y.Y.2; Chen M.1; Hu L.1; Chen X.1; Cheung E.1
2018-12-01
Source PublicationMolecular Cancer Research
ISSN15573125 15417786
Volume16Issue:12Pages:1865-1878
Abstract

The human genome is mostly transcribed, yielding a rich repository of noncoding transcripts that are involved in a myriad of biological processes including cancer. However, how many noncoding transcripts such as long noncoding RNAs (lncRNA) function in cancer is still unclear. This study identified a novel set of clinically relevant androgen-regulated lncRNAs in prostate cancer. Among this group, LINC00844 was demonstrated to be a direct androgen-regulated target that is actively transcribed in androgen receptor (AR)–dependent prostate cancer cells. The expression of LINC00844 is higher in normal prostate compared with malignant and metastatic prostate cancer clinical specimens, and patients with low expression had a poor prognosis and significantly increased biochemical recurrence, suggesting LINC00844 functions in suppressing tumor progression and metastasis. Indeed, in vitro loss-of-function studies revealed that LINC00844 prevents prostate cancer cell migration and invasion. Moreover, findings from gene expression profiling analysis indicated that LINC00844 functions in trans, affecting global androgen-regulated gene transcription. Mechanistic evidence reveals that LINC00844 is important in facilitating AR binding to the chromatin. Finally, LINC00844 mediates its phenotypic effects in part by activating the expression of NDRG1, a crucial cancer metastasis suppressor. Collectively, LINC00844 is a novel coregulator of AR that plays a central role in the androgen transcriptional network and the development and progression of prostate cancer. Implications: This study highlights the function of the lncRNA, LINC00844, in regulating global AR-regulated genes in prostate cancer by modulating AR binding to chromatin.

DOI10.1158/1541-7786.MCR-18-0087
URLView the original
Indexed BySCI
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000452375800006
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Universidade de Macau
2.A-Star, Genome Institute of Singapore
3.Guangdong University of Technology
Recommended Citation
GB/T 7714
Lingadahalli S.,Jadhao S.,Sung Y.Y.,et al. Novel lncRNA LINC00844 regulates prostate cancer cell migration and invasion through AR signaling[J]. Molecular Cancer Research,2018,16(12):1865-1878.
APA Lingadahalli S..,Jadhao S..,Sung Y.Y..,Chen M..,Hu L..,...&Cheung E..(2018).Novel lncRNA LINC00844 regulates prostate cancer cell migration and invasion through AR signaling.Molecular Cancer Research,16(12),1865-1878.
MLA Lingadahalli S.,et al."Novel lncRNA LINC00844 regulates prostate cancer cell migration and invasion through AR signaling".Molecular Cancer Research 16.12(2018):1865-1878.
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