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Fibroblast growth factor receptor 3 is a negative regulator of bone growth
Deng C.; Wynshaw-Boris A.; Zhou F.; Kuo A.; Leder P.
1996
Source PublicationCell
ISSN00928674
Volume84Issue:6Pages:911-921
Abstract

Endochondral ossification is a major mode of bone formation that occurs as chondrocytes undergo proliferation, hypertrophy, cell death, and osteoblastic replacement. We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene to produce severe and progressive bone dysplasia with enhanced and prolonged endochondral bone growth. This growth is accompanied by expansion of proliferating and hypertrophic chondrocytes within the cartilaginous growth plate. Thus, FGFR-3 appears to regulate endochondral ossification by an essentially negative mechanism, limiting rather than promoting osteogenesis. In light of these mouse results, certain human disorders, such as achondroplasia, can be interpreted as gain-of-function mutations that activate the fundamentally negative growth control exerted by the FGFR-3 kinase.

DOI10.1016/S0092-8674(00)81069-7
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:A1996UC38100012
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Citation statistics
Cited Times [WOS]:810   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
AffiliationNational Institute of Diabetes and Digestive and Kidney Diseases
Recommended Citation
GB/T 7714
Deng C.,Wynshaw-Boris A.,Zhou F.,et al. Fibroblast growth factor receptor 3 is a negative regulator of bone growth[J]. Cell,1996,84(6):911-921.
APA Deng C.,Wynshaw-Boris A.,Zhou F.,Kuo A.,&Leder P..(1996).Fibroblast growth factor receptor 3 is a negative regulator of bone growth.Cell,84(6),911-921.
MLA Deng C.,et al."Fibroblast growth factor receptor 3 is a negative regulator of bone growth".Cell 84.6(1996):911-921.
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