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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
Ashcroft G.S.1; Yang X.3; Glick A.B.1; Weinstein M.3; Letterio J.J.1; Mizel D.E.2; Anzano M.1; Greenwell-Wild T.2; Wahl S.M.2; Deng C.3; Roberts A.B.1
1999
Source PublicationNature Cell Biology
ISSN14657392
Volume1Issue:5Pages:260-266
Abstract

The generation of animals lacking SMAD proteins, which transduce signals from transforming growth factor-β (TGF-β), has made it possible to explore the contribution of the SMAD proteins to TGF-β activity in vivo. Here we report that, in contrast to predictions made on the basis of the ability of exogenous TGF-β to improve wound healing, Smad3-null (Smad3) mice paradoxically show accelerated cutaneous wound healing compared with wild-type mice, characterized by an increased rate of re-epithelialization and significantly reduced local infiltration of monocytes. Smad3 keratinocytes show altered patterns of growth and migration, and Smad3 monocytes exhibit a selectively blunted chemotactic response to TGF-β. These data are, to our knowledge, the first to implicate Smad3 in specific pathways of tissue repair and in the modulation of keratinocyte and monocyte function in vivo.

DOI10.1038/12971
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000083169600013
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Cited Times [WOS]:670   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
Corresponding AuthorRoberts A.B.
Affiliation1.National Cancer Institute
2.National Institute of Dental and Craniofacial Research
3.National Institute of Diabetes and Digestive and Kidney Diseases
Recommended Citation
GB/T 7714
Ashcroft G.S.,Yang X.,Glick A.B.,et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response[J]. Nature Cell Biology,1999,1(5):260-266.
APA Ashcroft G.S..,Yang X..,Glick A.B..,Weinstein M..,Letterio J.J..,...&Roberts A.B..(1999).Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response.Nature Cell Biology,1(5),260-266.
MLA Ashcroft G.S.,et al."Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response".Nature Cell Biology 1.5(1999):260-266.
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