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Low levels of Sry transcripts cannot be the sole cause of B6-YTIR sex reversal
Xu X.3; Li C.1; Garrett-Beal L.4; Larson D.3; Wynshaw-Boris A.3; Deng C.-X.3
2001-06-21
Source PublicationGenesis
ISSN1526954X
Volume30Issue:1Pages:7-11
AbstractSry, a single-copy gene on the Y-chromosome, triggers the fetal gonad to begin testis differentiation in mammals. On the other hand, mutation or absence of Sry results in ovary differentiation and the female phenotype. However, cases of XY sex reversal in the presence of wild-type Sry exist in mice and man. One such example is the B6-Y mouse, whose autosomes and X-chromosome are from the C57BL/6J mouse (an inbred strain of Mus musculus molossinus), whereas the Y-chromosome is from a Mus musculus domesticus mouse originating in Tirano, Italy. The B6-Y mouse never develops normal testes and instead develops ovaries or ovotestes in fetal life. It has been suggested that low levels of Sry transcription may account for the aberrant testis differentiation in the B6-Y mouse. In this study, however, we observed relatively low levels of Sry transcripts not only in B6-Y but also in B6 mice, which develop normal testes. We conclude that low dosage of Sry transcripts cannot be the sole cause of sex reversal in the B6-Y gonad. © 2001 Wiley-Liss, Inc.
KeywordSex determination Sry transcription Testis XY sex reversal
DOI10.1002/gene.1026
URLView the original
Language英語
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.National Human Genome Research Institute
2.National Institutes of Health, Bethesda
3.National Institute of Diabetes and Digestive and Kidney Diseases
4.University of California, San Diego, School of Medicine
Recommended Citation
GB/T 7714
Xu X.,Li C.,Garrett-Beal L.,et al. Low levels of Sry transcripts cannot be the sole cause of B6-YTIR sex reversal[J]. Genesis,2001,30(1):7-11.
APA Xu X.,Li C.,Garrett-Beal L.,Larson D.,Wynshaw-Boris A.,&Deng C.-X..(2001).Low levels of Sry transcripts cannot be the sole cause of B6-YTIR sex reversal.Genesis,30(1),7-11.
MLA Xu X.,et al."Low levels of Sry transcripts cannot be the sole cause of B6-YTIR sex reversal".Genesis 30.1(2001):7-11.
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