UM
Ursolic Acid Attenuates Atherosclerosis in ApoE(-/-) Mice: Role of LOX-1 Mediated by ROS/NF-B Pathway
Li, Qiu; Zhao, Wenwen; Zeng, Xi; Hao, Zhihui
2018-05
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:5
AbstractAtherosclerosis, a chronic inflammatory disease, is a major contributor to cardiovascular diseases. Ursolic acid (UA) is a phytonutrient with widely biological effects including anti-oxidative, anti-inflammatory, and so on. At present, the effect of UA on atherosclerosis and the mechanism of action are still obscure. This study focused on investigating the effects of UA on atherosclerosis both in vivo and in vitro. We first selected LOX-1 as our target, which was reckoned as a new promising receptor for treating atherosclerosis. The evaluation in vitro suggested that UA significantly decreased endothelial LOX-1 expression induced by LPS both in mRNA and protein levels. Pre-treatment of UA also inhibited TLR4/MyD88 signaling activated by LPS. Moreover, UA reduced ROS production and suppressed the activation of NF-B stimulated by LPS. Particularly, the evaluation in vivo further verified the conclusion obtained in vitro. In ApoE(-/-) mice fed with an atherogenic diet, both UA (100 mg/kg/day) and simvastatin significantly attenuated atherosclerotic plaque formation and shrunk necrotic core areas. The enhanced expression of LOX-1 in atherosclerotic aorta was also dramatically decreased by administration of UA. Taken together, these results suggested that UA, with anti-atherosclerotic activity through inhibition of LOX-1 mediated by ROS/NF-B signaling pathways, may become a valuable vascular protective candidate for the treatment of atherosclerosis.
Keywordatherosclerosis ROS HUVECs LOX-1
DOI10.3390/molecules23051101
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000435204000116
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Li, Qiu,Zhao, Wenwen,Zeng, Xi,et al. Ursolic Acid Attenuates Atherosclerosis in ApoE(-/-) Mice: Role of LOX-1 Mediated by ROS/NF-B Pathway[J]. MOLECULES,2018,23(5).
APA Li, Qiu,Zhao, Wenwen,Zeng, Xi,&Hao, Zhihui.(2018).Ursolic Acid Attenuates Atherosclerosis in ApoE(-/-) Mice: Role of LOX-1 Mediated by ROS/NF-B Pathway.MOLECULES,23(5).
MLA Li, Qiu,et al."Ursolic Acid Attenuates Atherosclerosis in ApoE(-/-) Mice: Role of LOX-1 Mediated by ROS/NF-B Pathway".MOLECULES 23.5(2018).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Qiu]'s Articles
[Zhao, Wenwen]'s Articles
[Zeng, Xi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Qiu]'s Articles
[Zhao, Wenwen]'s Articles
[Zeng, Xi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Qiu]'s Articles
[Zhao, Wenwen]'s Articles
[Zeng, Xi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.