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Partial müllerian duct retention in Smad4 conditional mutant male mice
Petit F.G.2; Deng C.3; Jamin S.P.2
2016-04-21
Source PublicationInternational Journal of Biological Sciences
ISSN1449-2288
Volume12Issue:6Pages:667-676
Abstract

Müllerian duct regression is a complex process which involves the AMH signalling pathway. We have previously demonstrated that besides AMH and its specific type II receptor (AMHRII), BMPR-IA and Smad5 are two essential factors implicated in this mechanism. Mothers against decapentaplegic homolog 4 (Smad4) is a transcription factor and the common Smad (co-Smad) involved in transforming growth factor beta (TGF-β) signalling pathway superfamily. Since Smad4 null mutants die early during gastrulation, we have inactivated Smad4 in the Müllerian duct mesenchyme. Specific inactivation of Smad4 in the urogenital ridge leads to the partial persistence of the Müllerian duct in adult male mice. Careful examination of the urogenital tract reveals that the Müllerian duct retention is randomly distributed either on one side or both sides. Histological analysis shows a uterus-like structure, which is confirmed by the expression of estrogen receptor α. As previously described in a β-catenin conditional mutant mouse model, β-catenin contributes to Müllerian duct regression. In our mutant male embryos, it appears that β-catenin expression is locally reduced along the urogenital ridge as compared to control mice. Moreover, the expression pattern is similar to those observed in control female mice. This study shows that reduced Smad4 expression disrupts the Wnt/β-catenin signalling leading to the partial persistence of Müllerian duct.

KeywordConditional Knockout Müllerian Duct Smad4 Β-catenin
DOI10.7150/ijbs.12300
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000374665000004
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJamin S.P.
Affiliation1.Inserm
2.Universite de Rennes 1
3.Universidade de Macau
Recommended Citation
GB/T 7714
Petit F.G.,Deng C.,Jamin S.P.. Partial müllerian duct retention in Smad4 conditional mutant male mice[J]. International Journal of Biological Sciences,2016,12(6):667-676.
APA Petit F.G.,Deng C.,&Jamin S.P..(2016).Partial müllerian duct retention in Smad4 conditional mutant male mice.International Journal of Biological Sciences,12(6),667-676.
MLA Petit F.G.,et al."Partial müllerian duct retention in Smad4 conditional mutant male mice".International Journal of Biological Sciences 12.6(2016):667-676.
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