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Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase
Chen, Xian-Qiang; Zhao, Jing; Chen, Ling-Xiao; Wang, Shen-Fei; Wang, Ying; Li, Shao-Ping
2018-05
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume149Pages:103-115
Abstract

Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z(3), 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against alpha-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on alpha-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for alpha-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes. (C) 2018 Published by Elsevier Ltd.

KeywordGanoderma Resinaceum Ganodermataceae Lanostane Triterpenes Alpha-glucosidase Inhibitor
DOI10.1016/j.phytochem.2018.01.007
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000430778200009
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhao, Jing; Wang, Ying; Li, Shao-Ping
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Xian-Qiang,Zhao, Jing,Chen, Ling-Xiao,et al. Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase[J]. PHYTOCHEMISTRY,2018,149:103-115.
APA Chen, Xian-Qiang,Zhao, Jing,Chen, Ling-Xiao,Wang, Shen-Fei,Wang, Ying,&Li, Shao-Ping.(2018).Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase.PHYTOCHEMISTRY,149,103-115.
MLA Chen, Xian-Qiang,et al."Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase".PHYTOCHEMISTRY 149(2018):103-115.
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