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Reductive-Responsive, Single-Molecular-Layer Polymer Nanocapsules Prepared by Lateral-Functionalized Pillar[5]arenes for Targeting Anticancer Drug Delivery
Fu, Shuang1; Zhang, Yue1,2; Guan, Shuwen1,2; Huang, Qiaoxin2; Wang, Ruibing2; Tian, Ruizhen1; Zang, Mingsong1; Qiao, Shanpeng1; Zhang, Xin1; Liu, Shengda1; Fan, Xiaotong1; Li, Xiumei1; Luo, Quan1; Hou, Chunxi1; Xu, Jiayun1; Dong, Zeyuan1; Liu, Junqiu1
2018-05-02
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:17Pages:14281-14286
Abstract

Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery but also extends the design of smart materials for biomedical applications.

KeywordReductive-responsive Polymer Nanocapsules Pillar[n]Arene Host-guest Property Drug Delivery
DOI10.1021/acsami.8b03534
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000431723400008
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Supramolecular Structure and Materials, Collage of Chemistry, and ‡College of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, P.R. China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR 999078, China
Recommended Citation
GB/T 7714
Fu, Shuang,Zhang, Yue,Guan, Shuwen,et al. Reductive-Responsive, Single-Molecular-Layer Polymer Nanocapsules Prepared by Lateral-Functionalized Pillar[5]arenes for Targeting Anticancer Drug Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(17):14281-14286.
APA Fu, Shuang.,Zhang, Yue.,Guan, Shuwen.,Huang, Qiaoxin.,Wang, Ruibing.,...&Liu, Junqiu.(2018).Reductive-Responsive, Single-Molecular-Layer Polymer Nanocapsules Prepared by Lateral-Functionalized Pillar[5]arenes for Targeting Anticancer Drug Delivery.ACS APPLIED MATERIALS & INTERFACES,10(17),14281-14286.
MLA Fu, Shuang,et al."Reductive-Responsive, Single-Molecular-Layer Polymer Nanocapsules Prepared by Lateral-Functionalized Pillar[5]arenes for Targeting Anticancer Drug Delivery".ACS APPLIED MATERIALS & INTERFACES 10.17(2018):14281-14286.
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