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Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement
Eriksson, Peter1; Tal, Alexey A.2,5; Skallberg, Andreas1; Brommesson, Caroline1; Hu, Zhangjun1; Boyd, Robert D.3; Olovsson, Weine2; Fairley, Neal4; Abrikosov, Igor A.2,5; Zhang, Xuanjun6; Uvdal, Kajsa1
2018-05-03
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume8
Abstract

The chelating gadolinium-complex is routinely used as magnetic resonance imaging (MRI) -contrast enhancer. However, several safety issues have recently been reported by FDA and PRAC. There is an urgent need for the next generation of safer MRI-contrast enhancers, with improved local contrast and targeting capabilities. Cerium oxide nanoparticles (CeNPs) are designed with fractions of up to 50% gadolinium to utilize the superior MRI-contrast properties of gadolinium. CeNPs are well-tolerated in vivo and have redox properties making them suitable for biomedical applications, for example scavenging purposes on the tissue-and cellular level and during tumor treatment to reduce in vivo inflammatory processes. Our near edge X-ray absorption fine structure (NEXAFS) studies show that implementation of gadolinium changes the initial co-existence of oxidation states Ce3+ and Ce4+ of cerium, thereby affecting the scavenging properties of the nanoparticles. Based on ab initio electronic structure calculations, we describe the most prominent spectral features for the respective oxidation states. The as-prepared gadolinium-implemented CeNPs are 3-5 nm in size, have r(1)-relaxivities between 7-13 mM(-1) s(-1) and show clear antioxidative properties, all of which means they are promising theranostic agents for use in future biomedical applications.

DOI10.1038/s41598-018-25390-z
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000431293100003
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Division of Molecular Surface Physics and Nanoscience, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-581 83, Linköping, Sweden
2.Division of Theoretical Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-581 83, Linköping, Sweden
3.Division of Theoretical Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, SE-581 83, Linköping, Sweden
4.Casa Software Ltd, Bay House, 5 Grosvenor Terrace, Teignmouth, TQ14 8NE, United Kingdom
5.Materials Modeling and Development Laboratory, National University of Science and Technology “MISIS”, 119049, Moscow, Russia
6.Faculty of Health Sciences, University of Macau, Macau, SAR, China. Correspondence and requests for materials should be addressed to C.B.
Recommended Citation
GB/T 7714
Eriksson, Peter,Tal, Alexey A.,Skallberg, Andreas,et al. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement[J]. SCIENTIFIC REPORTS,2018,8.
APA Eriksson, Peter.,Tal, Alexey A..,Skallberg, Andreas.,Brommesson, Caroline.,Hu, Zhangjun.,...&Uvdal, Kajsa.(2018).Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement.SCIENTIFIC REPORTS,8.
MLA Eriksson, Peter,et al."Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement".SCIENTIFIC REPORTS 8(2018).
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