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Facile preparation of stable PEG-functionalized quantum dots with glycine-enhanced photoluminescence and their application for screening of aflatoxin B-1 in herbs
Zhang, Lei1; Dou, Xiaowen1; Zhang, Cheng1; Ying, Guangyao1; Liu, Congmin1; Luo, Jiaoyang1; Li, Qian1; Li, Peng2; Wang, Yitao2; Yang, Meihua1
2018-05-15
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume261Pages:188-195
Abstract

Rapid and sensitive analytical methods of measuring mycotoxin contamination levels in medicinal herbs are urgently needed. This paper proposes a novel immunoassay utilizing PEG-modified CdSe/CdS quantum dots (QDs) with signal enhancement by glycine for aflatoxin B-1 (AFB(1)) detection in medicinal herbs. Special attention was paid to the stability and photoluminescence (PL) properties of these QDs in multi-compound solutions. In this work, the dual ligands of 3-mercaptopropionic acid (MPA) and thiol-terminated methoxy PEG (mPEG-HS) were used collectively to overcome baffling coagulation and allowed for the successful transfer of hydrophobic QDs to aqueous solution. To maintain excellent PL intensity of the QDs, the ingenious solution of adding glycine was suggested, and the final PL intensity increased approximately 2 times compared to the baseline. The proposed surface modification significantly improved the colloidal stability and PL intensity of the QDs, as well as simplified the procedure compared to commonly used approaches. Furthermore, this is the first report of using these modified QDs as sensitive label for rapidly screening of AFB(1) in different medicinal herbs, with IC50 s ranging from 0.17 to 0.35 ng mL(-1). The QD labeling technique could potentially serve as a novel means of performing fast trace-detection in complex matrices. (C) 2018 Elsevier B.V. All rights reserved.

KeywordQuantum Dots Mpeg-hs Fluorescence Enhancement Aflatoxin Medicinal Herb Flisa
DOIhttp://doi.org/10.1016/j.snb.2018.01.124
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000426437400023
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Peng; Yang, Meihua
Affiliation1.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, Lei,Dou, Xiaowen,Zhang, Cheng,et al. Facile preparation of stable PEG-functionalized quantum dots with glycine-enhanced photoluminescence and their application for screening of aflatoxin B-1 in herbs[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,261:188-195.
APA Zhang, Lei.,Dou, Xiaowen.,Zhang, Cheng.,Ying, Guangyao.,Liu, Congmin.,...&Yang, Meihua.(2018).Facile preparation of stable PEG-functionalized quantum dots with glycine-enhanced photoluminescence and their application for screening of aflatoxin B-1 in herbs.SENSORS AND ACTUATORS B-CHEMICAL,261,188-195.
MLA Zhang, Lei,et al."Facile preparation of stable PEG-functionalized quantum dots with glycine-enhanced photoluminescence and their application for screening of aflatoxin B-1 in herbs".SENSORS AND ACTUATORS B-CHEMICAL 261(2018):188-195.
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