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Cellular pharmacological study of shikonin derivatives
Xin Chen; Lu Yang; Joost J Oppenheim; O.M.Zack Howard
2002
Source PublicationPhytotherapy Research
ISSN1099-1573
Volume16Issue:3Pages:199-209
Abstract

The naphthoquinone pigment, shikonin, isolated from Lithospermum erythrorhizon Sieb. et Zucc.(Boraginaceae) and its derivatives are the active components isolated from the Chinese herbal therapeutic, Zicao. Historically, Zicao root extracts have been used to treat macular eruption, measles, sore‐throat, carbuncles and burns. Multiple pharmacological actions have been attributed to shikonin, e.g. antiinflammatory, antigonadotropic and anti‐HIV‐1 activity. In this review, several therapeutic applications of shikonin will be summarized including its pleiotropic, antiinflammatory and antitumour effects. Widely diverse and sometimes conflicting activities have been attributed to shikonin, e.g. wound healing, enhanced granuloma formation, suppression of local acute inflammatory reactions, inhibition of angiogenesis, inhibition of select chemokine ligands, inhibition of DNA topoisomerase activity, inhibition of platelet activation and antimicrobial activity. Comparison of the various reported mechanisms of action for shikonin lead us to hypothesize that shikonin is an effective inhibitor of protein–protein interaction with multiple targets in both the intracellular and extracellular compartments. This general inhibitory effect can account for the broad spectrum of shikonin biological and pharmacological activities. Published in 2002 by John Wiley & Sons, Ltd.

KeywordShikonin Zicao Cellular Pharmacology Anti Tumour Antiinflammatory
DOIhttps://doi.org/10.1002/ptr.1100
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationLaboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute-Frederick, MD 21702-1201, USA
Recommended Citation
GB/T 7714
Xin Chen,Lu Yang,Joost J Oppenheim,et al. Cellular pharmacological study of shikonin derivatives[J]. Phytotherapy Research,2002,16(3):199-209.
APA Xin Chen,Lu Yang,Joost J Oppenheim,&O.M.Zack Howard.(2002).Cellular pharmacological study of shikonin derivatives.Phytotherapy Research,16(3),199-209.
MLA Xin Chen,et al."Cellular pharmacological study of shikonin derivatives".Phytotherapy Research 16.3(2002):199-209.
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