UM  > 中華醫藥研究院
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate
Zack Howard; Hui Fang Dong; Shao Bo Su; Rachel R. Caspi; Xin Chen; Paul Plotz; Joost J. Oppenheim
2005
Source PublicationBlood
ISSN0006-4971
Volume105Issue:11Pages:4207-4214
Abstract

We tested the hypothesis that interaction between autoantigens and chemoattractant receptors may be an important step in the development of autoimmunity. The retinal autoantigens S-antigen (S-Ag) and interphotoreceptor retinoid binding protein (IRBP) can induce autoimmune uveitis in rodent models. We evaluated the chemotactic activity of S-Ag and IRBP and found that both induced migration of human and mouse immature dendritic cells (iDCs) and lymphocytes, but not neutrophils, monocytes, or mature DCs. Cross-desensitization studies and single-receptor transfected cells revealed that subfamily of alpha chemokine receptors CXCR5 and CXCR3 mediated the chemotactic effect of IRBP, while only CXCR3 was required for the chemotactic response to S-Ag. Examination of the relationships between chemoattraction and the ability to elicit pathology at the protein or peptide levels in the mouse uveitis model revealed dissociation of the capacity to induce uveitis, lymphocyte proliferation, and chemoattraction. These studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5.

DOIhttps://doi.org/10.1182/blood-2004-07-2697
Language英语
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationNational Cancer Institute-Center for Cancer Research, Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation, Frederick, MD, USA
Recommended Citation
GB/T 7714
Zack Howard,Hui Fang Dong,Shao Bo Su,et al. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate[J]. Blood,2005,105(11):4207-4214.
APA Zack Howard.,Hui Fang Dong.,Shao Bo Su.,Rachel R. Caspi.,Xin Chen.,...&Joost J. Oppenheim.(2005).Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.Blood,105(11),4207-4214.
MLA Zack Howard,et al."Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate".Blood 105.11(2005):4207-4214.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zack Howard]'s Articles
[Hui Fang Dong]'s Articles
[Shao Bo Su]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zack Howard]'s Articles
[Hui Fang Dong]'s Articles
[Shao Bo Su]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zack Howard]'s Articles
[Hui Fang Dong]'s Articles
[Shao Bo Su]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.