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Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity (review)
Xin Chen1; Joost J Oppenheim2
2011
Source PublicationFEBS letters
ISSN0014-5793
Volume585Issue:23Pages:3611-3618
Abstract

Anti-TNF treatment is effective in a majority of rheumatoid arthritis (RA), however, this treatment can unexpectedly trigger the onset or exacerbate multiple sclerosis (MS). Recent progress in cellular immunology research provides a new framework to analyze the possible mechanism underlying these puzzling contradictory effects. The delicate balance of protective CD4(+)FoxP3(+) regulatory T cells (Tregs) and pathogenic CD4(+)FoxP3(-) effector T cells (Teffs) is crucial for the outcome of anti-TNF treatment of autoimmune disease. There is convincing evidence that TNF, in addition to stimulating Teffs, is able to activate and expand Tregs through TNFR2, which is preferentially expressed by Tregs. Therefore, the contrasting effects of TNF on Tregs and Teffs are likely to determine the therapeutic effect of anti-TNF treatment. In this review, we discuss the current understanding of the general effect of TNF on the activation of T cells, and the impact of TNF on the function of Teffs and Tregs. Understanding the differential effects of TNF on Teffs and Tregs is fundamentally required for the design of more effective and safer anti-TNF or anti-TNF receptor(s) therapeutic strategy for autoimmune diseases.

KeywordTnf Tnfr2 Regulatory t Cell Effector t Cel
DOIhttps://doi.org/10.1016/j.febslet.2011.04.025
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorJoost J Oppenheim
Affiliation1.Basic Science Program, SAIC-Frederick, Inc., Laboratory of Molecular Immunoregulation, NCI-Frederick, Frederick, MD 21702, USA
2.Laboratory of Molecular Immunoregulation, NCI-Frederick, Center for Cancer Research, Frederick, MD 21702, USA
Recommended Citation
GB/T 7714
Xin Chen,Joost J Oppenheim. Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity (review)[J]. FEBS letters,2011,585(23):3611-3618.
APA Xin Chen,&Joost J Oppenheim.(2011).Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity (review).FEBS letters,585(23),3611-3618.
MLA Xin Chen,et al."Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity (review)".FEBS letters 585.23(2011):3611-3618.
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