UM  > 中華醫藥研究院
Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells
Xin Chen1; Oppenheim JJ2
2011
Source PublicationInternational Immunopharmacology
ISSN1567-5769
Volume11Issue:10Pages:1489-1496
Abstract

Authenticating markers for the functional suppressive CD4+FoxP3+ regulatory T cells (Tregs) are important for the quantitative identification and enrichment of viable Tregs for possible therapeutic use. CD25 as a surrogate marker of Tregs has some limitations, which prompted investigators to identify more specific marker(s) of Tregs. The search for a firm molecular definition of Tregs resulted in the identification of FoxP3 as a better marker of this subset of CD4 cells. Nevertheless, FoxP3+ Tregs are phenotypically and functionally heterogeneous. Even in normal mice, only a minority of FoxP3+ T cells are potent suppressor cells. Therefore, additional marker(s) are required for delineation of truly functional Tregs. In this review, the studies identifying markers of functional Tregs, both in mouse and in human, and their functional implications are discussed. Our finding that TNFR2, which mediates the effect of TNF on the activation of Tregs, is a superb marker of the most suppressive subset of mouse Tregs and its application in the identification of functional human Tregs will also be reviewed.

KeywordRegulatory t Cells Cellular Markers Immunosuppressive Function
DOIhttps://doi.org/10.1016/j.intimp.2011.05.018
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Pharmacology & Pharmacy
WOS SubjectImmunology ; Pharmacology & Pharmacy
WOS IDWOS:000296000000012
Fulltext Access
Citation statistics
Cited Times [WOS]:45   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXin Chen
Affiliation1.Basic Science Program, SAIC-Frederick, Inc., Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, NCI-Frederick, Frederick, Maryland 21702, United States
2.Laboratory of Molecular Immunoregulation, NCI-Frederick, Cancer Inflammation Program, Center for Cancer Research, Frederick, Maryland 21702, United States
Recommended Citation
GB/T 7714
Xin Chen,Oppenheim JJ. Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells[J]. International Immunopharmacology,2011,11(10):1489-1496.
APA Xin Chen,&Oppenheim JJ.(2011).Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells.International Immunopharmacology,11(10),1489-1496.
MLA Xin Chen,et al."Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells".International Immunopharmacology 11.10(2011):1489-1496.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xin Chen]'s Articles
[Oppenheim JJ]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xin Chen]'s Articles
[Oppenheim JJ]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xin Chen]'s Articles
[Oppenheim JJ]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.