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Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity
Xin Chen1,2; Joost J Oppenheim2
2016
Source PublicationNature Reviews Rheumatology
ISSN1759-4790
Volume12Issue:11Pages:625–626
Other Abstract

Adalimumab, an anti-TNF monoclonal antibody used to treat rheumatoid arthritis and other autoimmune disorders, paradoxically enhances the capacity of TNF to expand TNF receptor type II‑expressing regulatory T cells. This provocative finding opens a new avenue for exploring the mechanisms that underlie efficacy, non-responsiveness and adverse effects associated with therapeutic targeting of TNF signalling.

KeywordAutoimmunity Rheumatoid Arthritis t Cells Tumour-necrosis Factors
DOIhttps://doi.org/10.1038/nrrheum.2016.145
Indexed BySCI
WOS Research AreaRheumatology
WOS SubjectRheumatology
WOS IDWOS:000387055000001
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXin Chen; Joost J Oppenheim
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China
2.the Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xin Chen,Joost J Oppenheim. Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity[J]. Nature Reviews Rheumatology,2016,12(11):625–626.
APA Xin Chen,&Joost J Oppenheim.(2016).Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity.Nature Reviews Rheumatology,12(11),625–626.
MLA Xin Chen,et al."Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity".Nature Reviews Rheumatology 12.11(2016):625–626.
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