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In vitro performance of an injectable hydrogel/microsphere based immunocyte delivery system for localised anti-tumour activity
Chunming Wang; Gerard N. Adrianus; Nan Sheng; Shikai Toh; Yihong Gong; Dong-An Wang
2009-12
Source PublicationBiomaterials
ISSN0142-9612
Volume30Issue:36Pages:6986-6995
Abstract

The current practice of cell immunotherapy against cancer has encountered a substantial challenge, that is, targeted delivery of therapeutic cells to tumour sites is not favourably managed. In this study, we aimed to provide an engineering solution to govern the cell targeting and actions, for which a biomaterial model is developed to mediate the conveyance and accommodation of activated immunocytes with anti-cancer potentials. We fabricated a dual-layered hydrogel/microsphere (GS) composite, which preserves all advantageous features of hydrogel such as injectability and favourable permeability, to achieve genuine localisation and physical immobilisation of the executing immunocytes–macrophages. According to our presented in vitroinvestigations, the GS immunoconstruct exhibited effective elimination of carcinoma cells as well as high safety free of gene alteration or cell leakage. Notably, unwanted long-term proliferation of the delivered cells was restrained by physical encapsulation in the bio-inert 3D hydrogel frameworks. By these efforts, we have provided an immunocyte delivery platform with which cell-based immunotherapy can be initiated at a desired location and implemented in a controlled manner.

KeywordHydrogel Microsphere Macrophage Cytokine Apoptosis Cancer Immunotherapy
DOIhttps://doi.org/10.1016/j.biomaterials.2009.09.006
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000272071400020
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationDivision of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, N1.3-B2-13, Singapore 637457, Republic of Singapore
Recommended Citation
GB/T 7714
Chunming Wang,Gerard N. Adrianus,Nan Sheng,et al. In vitro performance of an injectable hydrogel/microsphere based immunocyte delivery system for localised anti-tumour activity[J]. Biomaterials,2009,30(36):6986-6995.
APA Chunming Wang,Gerard N. Adrianus,Nan Sheng,Shikai Toh,Yihong Gong,&Dong-An Wang.(2009).In vitro performance of an injectable hydrogel/microsphere based immunocyte delivery system for localised anti-tumour activity.Biomaterials,30(36),6986-6995.
MLA Chunming Wang,et al."In vitro performance of an injectable hydrogel/microsphere based immunocyte delivery system for localised anti-tumour activity".Biomaterials 30.36(2009):6986-6995.
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