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An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity
Chunming Wang; Dong-An Wang
2010-03-22
Source PublicationJournal of Materials Chemistry
ISSN0959-9428
Volume20Issue:16Pages:3166–3170
Abstract

Nanomaterials hold great promise in various biomedical applications such as biosensing, vaccination, and drug delivery. However, previous studies have raised an important caveat that common nanomaterials are toxic to many mammalian cells, which is generally owing to the cellular uptake of nanoparticles or debris. This concern has substantially hampered the development of nanomaterial-mediated cell delivery. In this work, we demonstrated a hydrogel/functionalised-nanoaggregate composite that can support survival and spreading of human mesenchymal stem cells in three-dimensional matrices, and prevented the potential toxicity of nanoparticles by harnessing the unique encapsulation of hydrogel scaffolds. Therefore, for the first time, we designed an injectable, nanomaterial-based platform for therapeutic cell delivery, and believe this work may contribute to the various communities of biology, chemistry and physics, especially to the specialists working in the diverse fields of nanomaterials science, tissue engineering, cell biology and toxicology.

DOIhttps://doi.org/10.1039/b926392f
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
WOS IDWOS:000276373500005
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被引频次[WOS]:4   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
AffiliationDivision of Bioengineering, School of Chemical & Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, N1.3-B2-13, Singapore
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Chunming Wang,Dong-An Wang. An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity[J]. Journal of Materials Chemistry,2010,20(16):3166–3170.
APA Chunming Wang,&Dong-An Wang.(2010).An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity.Journal of Materials Chemistry,20(16),3166–3170.
MLA Chunming Wang,et al."An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity".Journal of Materials Chemistry 20.16(2010):3166–3170.
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