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Engineered delivery strategies for enhanced control of growth factor activities in wound healing
Yiming Niu1; Qiu Li1; Ya Ding3; Lei Dong2; Chunming Wang1
2018-06-05
Source PublicationAdvanced Drug Delivery Reviews
ISSN0169-409X
Abstract

Growth factors (GFs) are versatile signalling molecules that orchestrate the dynamic, multi-stage process of wound healing. Delivery of exogenous GFs to the wound milieu to mediate healing in an active, physiologically-relevant manner has shown great promise in laboratories; however, the inherent instability of GFs, accompanied with numerous safety, efficacy and cost concerns, has hindered the clinical success of GF delivery. In this article, we highlight that the key to overcoming these challenges is to enhance the control of the activities of GFs throughout the delivering process. We summarise the recent strategies based on biomaterials matrices and molecular engineering, which aim to improve the conditions of GFs for delivery (at the ‘supply’ end of the delivery), increase the stability and functions of GFs in extracellular matrix (in transportation to target cells), as well as enhance the GFs/receptor interaction on the cell membrane (at the ‘destination’ end of the delivery). Many of these investigations have led to encouraging outcomes in various in vitro and in vivo regenerative models with considerable translational potential.

KeywordBiomaterials Scaffolds Controlled Delivery System Skin Tissue Regeneration Molecular Engineering Extracellular Matrix Glycosaminoglycan-protein Interaction Therapeutic Angiogenesis
DOIhttps://doi.org/10.1016/j.addr.2018.06.002
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau SAR, China
2.State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
3.State Key Laboratory of Natural Medicines, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yiming Niu,Qiu Li,Ya Ding,et al. Engineered delivery strategies for enhanced control of growth factor activities in wound healing[J]. Advanced Drug Delivery Reviews,2018.
APA Yiming Niu,Qiu Li,Ya Ding,Lei Dong,&Chunming Wang.(2018).Engineered delivery strategies for enhanced control of growth factor activities in wound healing.Advanced Drug Delivery Reviews.
MLA Yiming Niu,et al."Engineered delivery strategies for enhanced control of growth factor activities in wound healing".Advanced Drug Delivery Reviews (2018).
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