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Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review
Chen RE; Zhang JM; Hu YY; Wang SP; Chen MW; Wang YT
2014
Source PublicationAmerican Journal of Chinese Medicine
ISSN1793-6853
Volume42Issue:2Pages:275–288
Abstract

Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells involving multi-channel mechanisms, including the disruption of cell cycle, induction of apoptosis, anti-metastasis, antiangiogenic, and strengthening of immune function. Experimental data have revealed AE as a potentially potent anti-cancer candidate. Despite this, the pharmaceutical application of AE is still in a fledging period as most research has concentrated on the elucidation of the molecular mechanism of action of existing treatments, rather than the development of novel formulations. Therefore, the present review summarizes the potential toxicity, molecular mechanism, pharmacokinetic characteristics, and pharmaceutical development of AE as an antineoplastic agent. This is based on its physicochemical properties, in an attempt to encourage further research on AE as a potential anti-cancer agent.

KeywordAloe-emodin Chemotherapy Toxicity Anti-cancer Activity Review
DOIhttps://doi.org/10.1142/S0192415X14500189
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000333091500002
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, University of Macau Macau SAR, 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen RE,Zhang JM,Hu YY,et al. Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review[J]. American Journal of Chinese Medicine,2014,42(2):275–288.
APA Chen RE,Zhang JM,Hu YY,Wang SP,Chen MW,&Wang YT.(2014).Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review.American Journal of Chinese Medicine,42(2),275–288.
MLA Chen RE,et al."Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review".American Journal of Chinese Medicine 42.2(2014):275–288.
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