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Recent advances in nanoparticle formulation of oleanolic acid
Chen MW; Zhong ZF; Tan W; Wang SP; Wang YT
2011
Source PublicationChinese Medicine
ISSN1991-0150
Volume6Issue:20
Abstract

Oleanolic acid (OA) is a natural triterpenoid possessing anti-inflammatory, antitumor, antiviral, hepatoprotective and antihyperlipidemic effects. Research on the pharmacological activities and clinical applications of OA has made significant progress in the past decade, particularly in the areas such as isolation and purification, chemical modifications, pharmacological research, toxicity studies and clinical use of OA. However, due to its poor aqueous solubility, instability and low bioavailability, OA's clinical applications are still rather limited. Recently, nanoparticulate drug delivery as the biological dimension of nanotechnology has been developed, which may help generate useful formulations of OA for clinical applications. Nanoparticulate drug delivery system enhances the dissolution rate and bioavailability of OA, providing a feasible formulation method for clinical applications.

KeywordOleanolic Acid Solid Lipid Nanoparticles Poor Aqueous Solubility Nanoparticulate Drug Delivery System Antihyperlipidemic Effect
DOIhttps://doi.org/10.1186/1749-8546-6-20
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000208722100020
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Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen MW,Zhong ZF,Tan W,et al. Recent advances in nanoparticle formulation of oleanolic acid[J]. Chinese Medicine,2011,6(20).
APA Chen MW,Zhong ZF,Tan W,Wang SP,&Wang YT.(2011).Recent advances in nanoparticle formulation of oleanolic acid.Chinese Medicine,6(20).
MLA Chen MW,et al."Recent advances in nanoparticle formulation of oleanolic acid".Chinese Medicine 6.20(2011).
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