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Adiponectin: A biomarker for rheumatoid arthritis?
Chen XP1,2; Lu JJ1; Bao JL1; Guo JJ1; Shi JS2; Wang YT1
2013
Source PublicationCytokine & Growth Factor Reviews
ISSN1359-6101
Volume24Issue:1Pages:83-89
Abstract

Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications, such as atherosclerosis and type 2 diabetes, but also inflammatory- and immune-related disorders, such as rheumatoid arthritis (RA) and osteoarthritis (OA). A large number of these mediators, called adipokines, such as tumor necrosis factor alpha (TNF-α), leptin, adiponectin, resistin, chemerin, interleukin-6 (IL-6), visfatin, and so on have been identified and studied widely. Important advances related to these proteins shed new insights into the pathophysiological mechanisms of many complicated diseases, although details of which remain unclear. Adiponectin, one of the most widely investigated adipokine, has been shown to possess both anti- and pro-inflammatory effects. RA is a chronic systemic inflammatory-related autoimmune disease. Accumulated evidence has demonstrated that cytokines and adipokines play an important role in the pathogenesis of RA. In this review, we have summarized the most recent advances in adiponectin research in the context of RA, focusing primarily on its effect on RA-related cells, its regulation on pro-inflammatory cytokines, as well as its validation as a biomarker for RA.

KeywordAdiponectin Rheumatoid Arthritis Biomarker Inflammation
DOIhttps://doi.org/10.1016/j.cytogfr.2012.07.004
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000316436200008
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Cited Times [WOS]:39   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Department of Pharmacology and Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College, Zunyi, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen XP,Lu JJ,Bao JL,et al. Adiponectin: A biomarker for rheumatoid arthritis?[J]. Cytokine & Growth Factor Reviews,2013,24(1):83-89.
APA Chen XP,Lu JJ,Bao JL,Guo JJ,Shi JS,&Wang YT.(2013).Adiponectin: A biomarker for rheumatoid arthritis?.Cytokine & Growth Factor Reviews,24(1),83-89.
MLA Chen XP,et al."Adiponectin: A biomarker for rheumatoid arthritis?".Cytokine & Growth Factor Reviews 24.1(2013):83-89.
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