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Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease
Ying‐Qi Xu1; Zhong‐Qing Sun2; Yi‐Tao Wang1; Fei Xiao1,2; Mei‐Wan Chen1
2015-03-02
Source PublicationCNS: Neuroscience & Therapeutics
ISSN1755-5930
Volume21Issue:6Pages:479-485
Other Abstract

Nogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer’s disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer’s disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid b-protein (Ab), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo-A/Nogo-A receptor provide new insight into potential mechanisms and promising therapy strategies in AD.

KeywordAlzheimer's Disease Nogo-a Nogo-a Receptor
DOIhttps://doi.org/10.1111/cns.12387
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ying‐Qi Xu,Zhong‐Qing Sun,Yi‐Tao Wang,et al. Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease[J]. CNS: Neuroscience & Therapeutics,2015,21(6):479-485.
APA Ying‐Qi Xu,Zhong‐Qing Sun,Yi‐Tao Wang,Fei Xiao,&Mei‐Wan Chen.(2015).Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease.CNS: Neuroscience & Therapeutics,21(6),479-485.
MLA Ying‐Qi Xu,et al."Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease".CNS: Neuroscience & Therapeutics 21.6(2015):479-485.
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