Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease | |
Ying‐Qi Xu1; Zhong‐Qing Sun2; Yi‐Tao Wang1![]() | |
2015-03-02 | |
Source Publication | CNS: Neuroscience & Therapeutics
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ISSN | 1755-5930 |
Volume | 21Issue:6Pages:479-485 |
Other Abstract | Nogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer’s disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer’s disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid b-protein (Ab), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo-A/Nogo-A receptor provide new insight into potential mechanisms and promising therapy strategies in AD. |
Keyword | Alzheimer's Disease Nogo-a Nogo-a Receptor |
DOI | https://doi.org/10.1111/cns.12387 |
Language | 英语 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China 2.Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China |
First Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Ying‐Qi Xu,Zhong‐Qing Sun,Yi‐Tao Wang,et al. Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease[J]. CNS: Neuroscience & Therapeutics,2015,21(6):479-485. |
APA | Ying‐Qi Xu,Zhong‐Qing Sun,Yi‐Tao Wang,Fei Xiao,&Mei‐Wan Chen.(2015).Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease.CNS: Neuroscience & Therapeutics,21(6),479-485. |
MLA | Ying‐Qi Xu,et al."Function of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease".CNS: Neuroscience & Therapeutics 21.6(2015):479-485. |
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