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Advances in self-assembled chitosan nanomaterials for drug delivery
Yang Y1; Wang SP1; Wang YT1; Wang XH1,2; Wang Q3,4; Chen MW1
2014
Source PublicationBiotechnology Advances
ISSN0734-9750
Volume32Issue:7Pages:1301-1316
Abstract

Nanomaterials based on chitosan have emerged as promising carriers of therapeutic agents for drug delivery due to good biocompatibility, biodegradability, and low toxicity. Chitosan originated nanocarriers have been prepared by mini-emulsion, chemical or ionic gelation, coacervation/precipitation, and spray-drying methods. As alternatives to these traditional fabrication methods, self-assembled chitosan nanomaterials show significant advantages and have received growing scientific attention in recent years. Self-assembly is a spontaneous process by which organized structures with particular functions and properties could be obtained without additional complicated processing or modification steps. In this review, we focus on recent progress in the design, fabrication and physicochemical aspects of chitosan-based self-assembled nanomaterials. Their applications in drug delivery of different therapeutic agents are also discussed in details.

KeywordChitosan Self-assembly Nanomaterials Drug Delivery
DOIhttps://doi.org/10.1016/j.biotechadv.2014.07.007
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000343685000008
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Cited Times [WOS]:157   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
2.State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
3.Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
4.Department of Civil, Construction and Environmental Engineering, Iowa State University, Ames, IA 50011, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang Y,Wang SP,Wang YT,et al. Advances in self-assembled chitosan nanomaterials for drug delivery[J]. Biotechnology Advances,2014,32(7):1301-1316.
APA Yang Y,Wang SP,Wang YT,Wang XH,Wang Q,&Chen MW.(2014).Advances in self-assembled chitosan nanomaterials for drug delivery.Biotechnology Advances,32(7),1301-1316.
MLA Yang Y,et al."Advances in self-assembled chitosan nanomaterials for drug delivery".Biotechnology Advances 32.7(2014):1301-1316.
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