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Potent natural products and herbal medicines for treating liver fibrosis
Chen SR; Chen XP; Lu JJ; Wang Y; Wang YT
2015
Source PublicationChinese Medicine
ISSN1991-0150
Volume10Issue:7
Abstract

Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways. This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

KeywordLiver Fibrosis Silymarin Oleanolic Acid Silybin Fibrotic Liver
DOIhttp://dx.doi.org/10.1186/s13020-015-0036-y
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000353105500001
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang Y; Wang YT
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, SAR China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen SR,Chen XP,Lu JJ,et al. Potent natural products and herbal medicines for treating liver fibrosis[J]. Chinese Medicine,2015,10(7).
APA Chen SR,Chen XP,Lu JJ,Wang Y,&Wang YT.(2015).Potent natural products and herbal medicines for treating liver fibrosis.Chinese Medicine,10(7).
MLA Chen SR,et al."Potent natural products and herbal medicines for treating liver fibrosis".Chinese Medicine 10.7(2015).
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