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Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects
Liu JJ; Zhan XD; Wan JB; Wang YT; Wang CM
2015
Source PublicationCarbohydrate Polymers
ISSN0144-8617
Volume121Pages:27-36
Abstract

Carrageenan (CRG) is a family of natural polysaccharides derived from seaweeds and has widely been used as food additives. In the past decade, owing to its attractive physicochemical properties, CRG has been developed into versatile biomaterials vehicles for drug delivery. Nevertheless, studies also emerged to reveal its adverse effects on the biological system. In this review, we critically appraise the latest literature (two thirds since 2008) on the development of CRG-based pharmaceutical vehicles and the perspective of using CRG for broader biomedical applications. We focus on how current strategies exploit the unique gelling mechanisms, strong water absorption and abundant functional groups of the three major CRG varieties. Notably, CRG-based matrices are demonstrated to increase drug loading and drug solubility, enabling release of orally administrated drugs in zero-order or in a significantly prolonged period. Other amazing features, such as pH-sensitivity and adhesive property, of CRG-based formulations are also introduced. Finally, we discuss the adverse influence of CRG on the human body and then suggest some future directions for the development of CRG-based biomaterials for broader applications in biomedicine.

KeywordCarrageenan Polysaccharide Biomaterials Gelling Drug Release Cytotoxicity
DOIhttps://doi.org/10.1016/j.carbpol.2014.11.063
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000350182400004
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Cited Times [WOS]:74   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida Padre Tomas Pereira, Taipa, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu JJ,Zhan XD,Wan JB,et al. Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects[J]. Carbohydrate Polymers,2015,121:27-36.
APA Liu JJ,Zhan XD,Wan JB,Wang YT,&Wang CM.(2015).Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects.Carbohydrate Polymers,121,27-36.
MLA Liu JJ,et al."Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects".Carbohydrate Polymers 121(2015):27-36.
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