UM  > 中華醫藥研究院
Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer
Wang SP1; Qiu JG2; Shi Z1,2; Wang YT1; Chen MW1
2015
Source PublicationBiotechnology Advances
ISSN0734-9750
Volume33Issue:1Pages:224-241
Abstract

Taxanes are one type of the most extensively used chemotherapeutic agents to treat cancers. However, their clinical use is severely limited by intrinsic and acquired resistance. A diverse variety of mechanisms has been implicated about taxane resistance, such as alterations of drug targets, overexpression of efflux transporters, defective apoptotic machineries, and barriers in drug transport. The deepening understanding of molecular mechanisms of taxane resistance has spawned a number of targets for reversing resistance. However, circumvention of taxane resistance would not only possess therapeutic potential, but also face with clinical challenge, which accelerates the development of optimal nanoscale delivery systems. This review highlights the current understanding on the mechanisms of taxane resistance, and provides a comprehensive analysis of various nanoscale delivery systems to reverse taxane resistance.

KeywordCancer Multidrug Resistance Nanoparticles Taxanes
DOIhttps://doi.org/10.1016/j.biotechadv.2014.10.011
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000351321400017
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang SP,Qiu JG,Shi Z,et al. Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer[J]. Biotechnology Advances,2015,33(1):224-241.
APA Wang SP,Qiu JG,Shi Z,Wang YT,&Chen MW.(2015).Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer.Biotechnology Advances,33(1),224-241.
MLA Wang SP,et al."Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer".Biotechnology Advances 33.1(2015):224-241.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang SP]'s Articles
[Qiu JG]'s Articles
[Shi Z]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang SP]'s Articles
[Qiu JG]'s Articles
[Shi Z]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang SP]'s Articles
[Qiu JG]'s Articles
[Shi Z]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.