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Chinese Herbs Interfering with Cancer Reprogramming Metabolism
Zhong ZF1; Qiang WW2; Tan W3; Zhang HT1; Wang SP1; Wang CM1; Qiang WN4; Wang YT1
2016
Source PublicationEvidence-Based Complementary and Alternative Medicine
ISSN1741-427X
Volume2016
Abstract

Emerging evidence promotes a reassessment of metabolic reprogramming regulation in cancer research. Although there exists a long history of Chinese herbs applied in cancer treatment, few reports have addressed the effects of Chinese herbal components on metabolic reprogramming, which is a central cancer hallmark involved in the slowing or prevention of chemoresistance in cancer cells. In this review, we have focused on four core elements altered by metabolic reprogramming in cancer cells. These include glucose transport, glycolysis, mitochondrial oxidative phosphorylation, and fatty acid synthesis. With this focus, we have summarized recent advances in metabolic reprogramming of cancer cells in response to specific Chinese herbal components. We propose that exploring Chinese herbal interference in cancer metabolic reprogramming might identify new therapeutic targets for cancer and more ways in which to approach metabolism-related diseases.

DOIhttp://dx.doi.org/10.1155/2016/9282813
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000377045900001
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
2.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau; Yale University, New Haven, CT 06511, USA.
3.School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China.
4.Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhong ZF,Qiang WW,Tan W,et al. Chinese Herbs Interfering with Cancer Reprogramming Metabolism[J]. Evidence-Based Complementary and Alternative Medicine,2016,2016.
APA Zhong ZF.,Qiang WW.,Tan W.,Zhang HT.,Wang SP.,...&Wang YT.(2016).Chinese Herbs Interfering with Cancer Reprogramming Metabolism.Evidence-Based Complementary and Alternative Medicine,2016.
MLA Zhong ZF,et al."Chinese Herbs Interfering with Cancer Reprogramming Metabolism".Evidence-Based Complementary and Alternative Medicine 2016(2016).
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